Pair Name | Polyphyllin I, Cisplatin | ||
Phytochemical Name | Polyphyllin I (PubChem CID: 72960700 ) | ||
Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Polyphyllin I, Cisplatin | |||
Disease Info | [ICD-11: 2C25] | Lung cancer | Investigative | |
Biological Phenomena | Induction-->Apoptosis | |||
Gene Regulation | Down-regulation | Expression | AKT1 | hsa207 |
Up-regulation | Expression | BAX | hsa581 | |
Down-regulation | Expression | BCL2 | hsa596 | |
Up-regulation | Cleavage | CASP3 | hsa836 | |
Up-regulation | Expression | CDH1 | hsa999 | |
Down-regulation | Expression | CIP2A | hsa57650 | |
Up-regulation | Expression | MTOR | hsa2475 | |
Up-regulation | Cleavage | PARP1 | hsa142 | |
Down-regulation | Expression | TP53 | hsa7157 | |
Down-regulation | Expression | VIM | hsa7431 | |
In Vitro Model | A-549/DDP | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 |
Result | The results from the present study demonstrated that PPI and PPVII may function as chemosensitizers by enhancing apoptosis via the p53 pathway, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis, and the combination with DDP may be a promising strategy for the development of new therapeutic agents. |
No. | Title | Href |
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1 | Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis. Oncol Lett. 2019 Nov;18(5):5428-5436. doi: 10.3892/ol.2019.10895. | Click |