Pair Name	Polyphyllin I, Cisplatin
Disease Info	[ICD-11: 2C25.Z]	Lung cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	CIP2A	hsa57650
	Down-regulation	Expression	AKT1	hsa207
	Up-regulation	Expression	MTOR	hsa2475
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	VIM	hsa7431
In Vitro Model	A-549/DDP	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	The results from the present study demonstrated that PPI and PPVII may function as chemosensitizers by enhancing apoptosis via the p53 pathway, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis, and the combination with DDP may be a promising strategy for the development of new therapeutic agents.